The Effect of Casein Phosphopeptide Amorphous Calcium Phosphate on Affected Dentine

Hams Hamed Abdelrahman132 enrolled

Overview

Teeth selected for intervention with Atraumatic Restorative Treatment will receive Glass Ionomer restorations (control) or MI varnish (test) before receiving the Glass Ionomer restoration

Patients selected to participate in the study will be randomly assigned into 2 groups. Group 1 (test): who will receive casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP) + ART in the teeth selected, excavating only the caries infected dentine and preserving the caries affected dentine. Group 2 (control): Who will receive ART only in the teeth selected, excavating only the caries infected dentine and preserving the caries affected dentine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

132

Conditions

Caries,Dental

Interventions

Casein phosphopeptide amorphous calcium phosphateDRUG

varnish containing calcium and phospate ions which act as a source for tooth remineralization

Atraumatic restorative treatmentPROCEDURE

excavation of dental caries and restoring with light cured Glass Ionomer Restoration

Eligibility

Sex: ALLMin age: 6 YearsMax age: 11 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Healthy patients. 2. Patients with an age range of 6-8 years old for clinical evaluation. 3. Patients ranking definitely positive or positive on Frankl scale. 4. Patients having at least 1 symptomless primary molar with caries extending to the dentine (International Caries Detection and Assessment System (ICDAS II) code 4, 5 \& 6). 5. The presence of the permanent successors when examined by periapical X-ray. 6. Patients who will agree to participate in the study. For the ex-vivo sample 1. Patients with an age range of 9-11 years old. 2. The selected teeth should have more than half of their roots physiologically resorbed when examined by periapical X-ray. Exclusion Criteria: 1. Patients with special health care needs (physical, mental or medical). 2. Primary molars that are mobile, ankylosed or have periapical pathology on initial examination clinically and radiographically.

Locations (1)

Faculty of Dentistry, Alexandria University

Alexandria, Egypt

Outcomes

Primary Outcomes

Evaluate the reparative ability of Casein Phosphopeptide Amorphous Calcium Phosphate varnish on caries affected dentine in primary molars.

this is by evaluating the clinical and radiographic data and also by descriptive histological assessment

Time frame: 12 months

Central Contacts

Mohamed A. Bayoumi, MSc

CONTACT

0122273853 mohamed.bayoumi@pua.edu.eg

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.