Pd1 Antibody Sintilimab ± Chemoradiotherapy for Locally Advanced Rectal Cancer

Inclusion Criteria: 1. Histologically proven colorectal adenocarcinoma; 2. Cohort 1: Biopsy tissues with IHC indicates deficient mismatch repair(dMMR),that is,the loss of at least one of the four proteins ,MSH1,MSH2,MSH6,PMS2;or gene detection implies MSI-H; Cohort 2: Biopsy tissues with IHC indicates proficient mismatch repair(pMMR),that is positivity of all four proteins ,MSH1,MSH2,MSH6,PMS2;or gene detection implies MSS/MSI-L 3. Clinical stage for rectal cancer patients is cT3-4N0M0 or cTxN+M0; 4. Preoperative staging methods: all patients need to accept digital rectal examination(DRE).Patients with rectal cancer undergo high-resolution MRI±ultrasound colonoscopy/transrectal ultrasound for preoperative staging. Perienteric lymph nodes with short diameter ≥10mm or the shape of lymph nodes and its MRI characteristics are consistent with typical lymph node metastasis. If endoscopic ultrasonography is used in combination, and there is a contradiction between staging methods, the data should be submitted to the evaluation team of our center for the accurate staging; 5. No symptoms of ileus; or ileus is alleviated after proximal colostomy. 6. No rectal surgery except preventative stoma; 7. No chemotherapy or radiotherapy; 8. No biotherapy (e.g.monoclonal antibodies), immunotherapy (e.g.anti-PD-1 antibody,anti-PD-L1 antibody,anti-PD-L2 antibody or CTLA-4 antibody),or other clinical trials agents; 9. No limit to previous endocrine therapy. 10. Age between 18 and 75 years; 11. ECOG performance status of 0 or 1; 12. Life expectancy: more than 2 years; 13. Hematopoietic: WBC\>3×109/L;PLT\>80×109/L; Hb\>90g/L; 14. Hepatic: ALT and AST\<2 times upper limit of normal (ULN); bilirubin\<1.5 times ULN; 15. Renal: creatinine \<1.5 times ULN or creatinine clearance ≥ 60 mL/min. Exclusion Criteria: 1. Arrhythmias require antiarrhythmic therapy (with the exception of β-blockers or digoxin), symptomatic coronary artery disease or local myocardial ischemia (myocardial infarction within the past 6 months) or congestive heart failure exceeding NYHA II; 2. Severe hypertension with poor control after medication; 3. A known history of testing positive for HIV or chronic hepatitis B or C (high copy virus DNA) at active stage; 4. Patients with active tuberculosis (TB) are receiving anti-tuberculosis treatment or have received anti-tuberculosis treatment within 1 year before screening; 5. Other active severe clinical infections (NCI-CTC5.0); 6. Apparent distant metastasis away from the pelvic before surgery; 7. Cachexia, organ function decompensation; 8. Previous pelvic or abdominal radiotherapy; 9. Multiple primary colorectal cancers; 10. Epilepsy require medical treatment (such as steroid or antiepileptic therapy); 11. Other malignancy within the past 5 years with the exception of effectively treated carcinoma in situ of the cervix or basal cell carcinoma of the skin; 12. Drug abuse and medical, psychological or social factors that may interfere with patients' participation in the study or affect the evaluation of the study; 13. Patients have any active autoimmune diseases or a history of autoimmune diseases(including but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, nephritis, hyperthyroidism and decreased thyroid function; patients with vitiligo or with complete remission of asthma in childhood and without any intervention in adulthood may be included; patients with asthma requiring bronchodilators intervention are not included. 14. Received any anti-infection vaccine (e.g. influenza vaccine, chickenpox vaccine, etc.) within 4 weeks before enrollment; 15. Complications require long-term treatment with immunosuppressive drugs, or requiring systemic or local use of immunosuppressive corticosteroids(\>10mg/day prednisone or other therapeutic hormones); 16. Known or suspected allergy to the study drugs or to any drugs related to this trial; 17. Any unstable condition or which endangers the patients' safety and compliance; 18. Pregnant or breast-feeding women who are fertile without effective contraception; 19. Refuse to sign the informed consent.