Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

French Society for Intensive Care862 enrolled

Overview

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases. Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results. Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Study Type

OBSERVATIONAL

Enrollment

862

Conditions

Intensive Care Unit Syndrome Hypercapnia Acute Respiratory Failure

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients ≥18 years old presenting with at least of the following items : 1. respiratory rate ≥ 25/min, 2. paradoxical motion of the abdomen, 3. intercostal retraction AND * a PaCO2 \> 45 cm H20 before ICU admission or within the 12 hours following ICU admission. Exclusion Criteria: * Refusal to give informed consent, * pregnancy, * \< 18 years patient, * dying patient

Locations (3)

CH Andre Migniot

Versailles, A, France

CHU Nantes

Nantes, France

CHU Toulouse

Toulouse, France

Outcomes

Primary Outcomes

Prevalence of hypercapnic acute respiratory failure in ICU

Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period

Time frame: Intensive Care Unit length stay (Usually 7 days)