Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers

Mahidol University28 enrolled

Overview

The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.

CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coronary Heart Disease Periodontitis

Interventions

non-surgical periodontal treatmentPROCEDURE

scaling and root planing, home care instruction

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months) * had at least 14 natural teeth excluding third molars Exclusion Criteria: * received anticoagulant drugs * had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months * pregnancy or lactation * presence or history of other infections * periodontal treatment within 6 months * tooth extractions within 2 months prior to the study.

Locations (3)

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University

Ratchathewi, Bangkok, Thailand

Department of Medicine, Rajavithi Hospital

Ratchathewi, Bangkok, Thailand

Mahidol University Faculty of Dentistry

Ratchathewi, Bangkok, Thailand

Outcomes

Primary Outcomes

change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment

change in plasma fibrinogen level (pg/mL)

Time frame: 3 months after non-surgical periodontal treatment

change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment

change in activator inhibitor 1 level (pg/mL)

Time frame: 3 months after non-surgical periodontal treatment

change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment

change in C-reactive protein level (mg/L)

Time frame: 3 months after non-surgical periodontal treatment

change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment

change in plasma fibrinogen level (pg/mL)

Time frame: 6 months after non-surgical periodontal treatment

change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment

change in activator inhibitor 1 level (pg/mL)

Time frame: 6 months after non-surgical periodontal treatment

change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment

change in C-reactive protein level (mg/L)

Time frame: 6 months after non-surgical periodontal treatment

Secondary Outcomes

change of bleeding on probing between baseline and 3 months after non-surgical periodontal treatment

percetage of sites with bleeding on probing

Data from ClinicalTrials.gov

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