Study on the Geometric Parameters and Hemodynamic Reference Range of Neonatal Heart.

Peking University Third Hospital400 enrolled

Overview

Perform bedside echocardiography on neonates (term and preterm infants) who were admitted to our neonatal department within 24 hours of birth, and establish a geometric reference range of neonatal cardiac ultrasound and explore the hemodynamic changes of early newborns. Bedside echocardiography were performed to measure the diameter of each heart cavity and large vessels, velocity of each valve and aorta, wall thickness, left ventricular systolic function, right heart Tei index, Tricuspid Annular Plane Systolic Excursion(TPASE) of term and preterm infants respectively on 0 day, 3d, 7d of life and postmenstrual age of 30 weeks, 32 weeks, 34 weeks and 36 weeks.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Echocardiography of Newborns

Eligibility

Sex: ALLMax age: 12 WeeksHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Infants with normal hearts (infants with small patent fora-men oval or small patent ductus arteriosus were not excluded). 2.Healthy preterm infant with no evidence of sepsis, renal failure. 3. Absence of other major congenital anomalies or syndromes 4. Prior written consent was obtained from the parents. Exclusion Criteria: * Infants with severe congenital malformations, either cardiac or non-cardiac.

Locations (1)

Peking University Third Hospital

Outcomes

Primary Outcomes

Reference range of cardiac geometric parameters of preterm infants based on different gestational ages, weights, days of age and body surface area.

Time frame: 0 day of life to PMA 36 weeks

Hemodynamic changes in full-term and preterm infants on 0~7days of life.

Time frame: 0~7days of life

Secondary Outcomes

Reference range of cardiac geometric parameters of full-term infants based on different weights, days of age and body surface area.