The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.
Study Type
OBSERVATIONAL
Enrollment
1,000
Department of Neurology , First Affiliated Hospital Fujian Medical University
Fuzhou, Fujian, China
RECRUITINGOverall outcomes in CADASIL patients
record the occurrence of stroke and use modified Rankin Scale (mRS) to measure the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability.
Time frame: From date of enrollment until the date of death from any cause, assessed up to 20years
The correlation of genotype and phenotype
Genotype is defined by NOTCH3 pathogenic variant position and phenotype is defined by clinical types and characteristics.
Time frame: From date of enrollment until the date of death from any cause, assessed up to 20years
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