Evaluation of Retinal and Vascular Features in Coats Disease After Intravitreal Injections of Ranibizumab

Federico II University5 enrolled

Overview

This study evaluates the retinal and vascular features in patients affected by Coats disease under the effects of Ranibizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography

Coats disease is an idiopathic retinal vascular disorder, occurs in young males, and is characterized by retinal telangiactasias, numerous yellowish exudates in the subretinal space, macular edema, hemorrhages and, in advanced end-stage, by exudative retinal detachment. Ranibizumab is a vascular endothelial growth factor antagonist represent an efficacy treatment acting on vascular hyperpermeability. The optical coherence tomography and optical coherence tomography angiography represent novel and non-invasive diagnostic techniques that allow a detailed analysis of retinal and vascular features. The study evaluates the changes in optical coherence tomography and optical coherence tomography angiography parameters at baseline and after three monthly injections of Ranibizumab in Coats disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coats Disease

Interventions

Ranibizumab InjectionDRUG

Ranibizumab Injection (0.5 mg/0.05 ml): Three monthly intravitreal injections

Eligibility

Sex: MALEMin age: 19 YearsMax age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age older than 18 years * diagnosis of Coats disease * treatment-naïve with Ranibizumab * absence of other vitreoretinal and vascular retinal diseases * absence of diabetes Exclusion Criteria: * age younger than 18 years * No diagnosis of Coats disease * previous treatments with Ranibizumab * presence of vitreoretinal and vascular retinal diseases * presence of diabetes

Locations (1)

University of Naples "Federico II"

Naples, Italy

Outcomes

Primary Outcomes

Study of retinal and vascular features in Coats disease after intravitreal injections of Ranibizumab

The effectiveness of Ranibizumab injections for treating Coats disease using optical coherence tomography (OCT). The parameters analyzed by OCT were: Central Macular Thickness (micron), Subfoveal Choroidal Thickness (micron)

Time frame: Three months

Study of retinal and vascular features in Coats disease after intravitreal injections of Ranibizumab

The effectiveness of Ranibizumab injections for treating Coats disease using optical coherence tomography angiography (OCTA) The parameters analyzed by OCTA were: retinal vessel density (%), choriocapillaris vessel density (%)

Time frame: Three months

Data from ClinicalTrials.gov

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