Expanded NIPT for Pregnancy Complications

University of California, San Francisco70 enrolled

Overview

This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including fetal growth restriction and severe preeclampsia.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Fetal Growth Restriction Preeclampsia Severe

Interventions

Expanded panel cell free DNA testing (non-invasive prenatal testing)GENETIC

Maternal blood sampling

Placental biopsyGENETIC

Post-delivery placental sampling

Umbilical cord bloodGENETIC

Post-delivery umbilical cord blood sampling

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of early onset (\< 34 weeks) severe fetal growth restriction, defined as estimated fetal weight less than 10th percentile with abnormal umbilical artery Dopplers OR estimated fetal weight less than 5th percentile alone OR biometric size at least 14 days behind expected dates Exclusion Criteria: * Maternal age \< 18 years * Multifetal gestation * Chronic hypertension require use of pharmacotherapy * Tobacco or drug use * Major congenital malformations

Locations (1)

University of California, San Francisco

San Francisco, California, United States