Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.
SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented \[1-6\]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.
Study Type
OBSERVATIONAL
Enrollment
30
University Hospital Hradec Kralove
Hradec Králové, Třebeš, Czechia
RECRUITINGFunctional capillary density (FCD)
Parameter describing the perfusion of the microcirculation
Time frame: One week
Proportion of perfused vessels (PPV)
Parameter describing the perfusion of the microcirculation
Time frame: One week
Vasospasm occurence
Occurence of vasospasms on angiography and/or transcranial Doppler
Time frame: One week
Circulatory incoherence
Deranged microcirculation in patients on catecholamines
Time frame: One week
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