Renal Arterial Denervation in Sympathetic Dysautonomia

Inclusion Criteria: * All patients included in a prospective manner must sign an informed written consent and meet ALL of the following criteria that are typical of the procedure according to the protocol of our center: * Be considered adequate and eligible by the group of doctors responsible for the patient and by the multidisciplinary team of the study. Over 18 years, not pregnant. * Poorly controlled arterial hypertension, under treatment with at least one antihypertensive drug. * In addition, poorly controlled hypertension + increased variability, considering as such a standard deviation\> 10 mmHg for systolic BP and\> 5 for the diastolic BP of patient´s blood pressure levels, measured by ABPM. * Renal arteries anatomy suitable for the procedure, considered by CT, MRI, ultrasound or angiography. * Some criteria of dysautonomia, following the consensus of the American Autonomous Society (AAS) and the European Federation of Autonomous Societies (EFAS) of 2018. or supine HTN. Defined as sBP ≥ 140 mmHg and / or dBP ≥ 90 mmHg, measured at least after 5 minutes of supine rest. Moderate forms (160-179 mmHg or dBP of 100-109 mmHg) or severe will preferably be included. (sBP≥ 180 mmHg and / or dBP ≥ 110 mmHg). Mild forms will be considered in conjunction with symptoms or other findings (ABPM) or nighttime HTN. Considered as such one that does not fall more than 10% compared to the daytime BP or even rises (riser). They will be considered in conjunction with symptoms or other findings (eg ABMP). * If the foregoing is not fulfilled, marked orthostatism (\> 30 mmHG in sBP and / or\> 10mmHG in dBP). * Life expectancy exceeding one year (not presenting terminal illness or any health condition for which a survival of less than one year is estimated). Exclusion Criteria: * eGFR \<30 mL / min / 1.73m2. * Monoxidin treatment. * Impossibility of informed consent by the patient or legal representative. * Impossibility for follow-up at least 1 year. * Do not fulfill inclusion criteria, assessed by the multidisciplinary team.