Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoartrithis

Inclusion Criteria: * Patients aged 55-70 years * Suffering from grade 2-3 OA was identified by two observers who differed accordingly Kellgren-Lawrence research scale * Absence of local or general infections * Haematological and biochemical analysis without significant changes being made cause contraindications * Patients can understand the nature of the study * Written informed consent is given to patients Exclusion Criteria: * Patients are not willing to obey the study protocol * There are signs of infection or positive serology for HIV, hepatitis and syphilis * There is a history of cancer both in the family and yourself and the value of the examination tumour marker exceeds normal limits * There is a congenital disease that causes significant deformity of the knee can interfere with cell applications and interpret results * Articular injection of the knee by any drug during the previous 3 months * Participate in any clinical trial or treatment 30 days before the study * Other conditions may, according to medical criteria, not support participation in this research * Patients are subordinates or low ranking members