Metabolomics Profiling Research of Human Cerebrospinal Fluid in Aging Process

Inclusion Criteria: Aging groups: 1. . Above 20 years. 2. . No history of central nerve system injury and neurologic illness 3. . ASA≦II 4. . Written informed consent from the patient Aged-related neurodegenerative diseases group: 1. . Above 60 years of age 2. . Medical record proved the history of Parkinsonism or Alzheimer disease 3. . ASA≦III 4. . Written informed consent from the patient or guardian by statute. Exclusion Criteria: 1. patient refuses to sign informed consent 2. patients with coagulopathy, systemic infective disease and severe liver and renal function impairment 3. patients with spine or brain tumor and CNS disease 4. the presence of severe and/or uncontrolled and/or unstable medical disease within 12 months prior to study (e.g. acute pancreatitis, stroke, liver cirrhosis, congestive heart failure, and systemic immune disorder etc 5. Concurrent participation or planning to participate in another interventional clinical trial (Concurrent participation in an observational trial allowed)