The Effect of Periodontal Treatment on Stress and Pregnancy Relationship

Tokat Gaziosmanpasa University84 enrolled

Overview

There is a relationship between stress and pregnancy gingivitis. This relationship may be double-sided.

The aim of this clinical study was to determine the effect of non-surgical mechanical periodontal treatment on sex steroid and stress markers at pregnancy gingivitis. A total of 84 subjects; 22 pregnant women with gingivitis (group 1) and 25 pregnant women with periodontal healthy (pregnant group), group 2), 22 non-pregnant women with gingivitis (group 3) and 15 non-pregnant women with periodontal healthy (non-pregnant group), group 4) participated in this study. Clinically, plaque index, gingival index, and probing pocket depth were measured at baseline and after therapy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Pregnancy Gingivitis

Interventions

Non-surgical periodontal treatmentOTHER

Non-surgical periodontal treatment was performed for pregnant and non-pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken from all patients baseline and after 8 weeks.

Saliva samplesOTHER

Saliva samples were taken from patients for the evaluation of sex steroid and stress markers baseline and after 8 weeks.

GCF samplesOTHER

GCF samples were taken from patients for the evaluation of stress markers baseline and after 8 weeks.

Eligibility

Sex: FEMALEMin age: 24 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * being between the ages of 24-50 * being pregnant for 23-30 weeks (for pregnant individuals) * not smoking. Exclusion Criteria: * using antimicrobial or anti-inflammatory therapy within the previous 3 months, * having systemic disease, * having periodontitis, * having deep caries lesions, and remnant roots and * having lactation

Outcomes

Primary Outcomes

Dehydroepiandrosterone (DHEA)

The changes in DHEA levels within 8 weeks. Higher values represent a worse outcome. The decrease in DHEA levels is expected after periodontal treatment.

Time frame: Baseline and after 8 weeks

estrogen

The changes in estrogen levels within 8 weeks. Higher values represent a worse outcome. The decrease in estrogen levels is expected after periodontal treatment.

Time frame: Baseline and after 8 weeks

Secondary Outcomes

Gingival index

The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.

Time frame: Baseline and after 8 weeks

Data from ClinicalTrials.gov

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