Influence of Hesperidin and Vitamin C on Uric Acid Concentration

University of Kiel40 enrolled

Overview

Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.

Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks. The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted. During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed. At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Higher Uric Acid Concentrations (>5,5 mg/dl)Healthy

Interventions

ControlDIETARY_SUPPLEMENT

study drink (two weeks)

HesperidinDIETARY_SUPPLEMENT

study drink + Hesperidin 600 mg (two weeks)

Vitamin CDIETARY_SUPPLEMENT

study drink + Vitamin C 250 mg (two weeks)

Hesperidin + Vitamin C

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy * higher uric acid concentration (≥5.5 mg/dL) * Informed written consent Exclusion Criteria: * pregnancy * fructose intolerance * smoking * gout or medicated hyperuricemia * diabetes mellitus * antidiabetic or cytostatic medication * weight loss (≥5% in the past 3 months) * consumption of vitamin C-containing supplements * parallel participation in a clinical trial * anemia and / or iron deficiency

Locations (1)

Institute of Human Nutrition

Kiel, Germany

Outcomes

Primary Outcomes

Changes in uric acid serum concentrations

measured via uric acid serum concentration (mg/dL)

Time frame: Baseline (pre) and post two weeks of intervention

Secondary Outcomes

changes in uric acid excretion

measured via uric acid excretion in 24h urine (mg/24h)

Time frame: Baseline (pre) and post two weeks of intervention

changes in pulse wave velocity

measured via oscillometric method (m/s)

Time frame: Baseline (pre) and post two weeks of intervention

insulin sensitivity

measured via minimal model from oral glucose tolerance test data using the particular study drink with added glucose to 75 g Glucose / 200 mL

Time frame: Baseline (pre) intervention periods

Data from ClinicalTrials.gov

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