Ketogenic Diet for Patients Receiving Treatment for Metastatic Renal Cell Carcinoma

Inclusion Criteria: 1. Subject with histologically-confirmed renal cell carcinoma 2. At least one CT-verified metastasis ≥ 10 mm, not previously irradiated 3. Treatment : PAZOPANIB, SUNITINIB, PEMBROLIZUMAB/AXITINIB or NIVOLUMAB/IPILIMUMAB (for first line), NIVOLUMAB, CABOZANTINIB, AXITINIB, SORAFENIB, TKI anti-VEGF, other therapy for second and third line of treatment 4. Men and women, aged ≥ 18 years 5. OMS ≤ 1 6. Screening laboratory values must meet the following criteria and should be obtained prior to commencement of treatment: 1. Hemoglobin ≥ 9 g/dL, neutrophils ≥ 1000 /mm3, platelets ≥ 100 000 /mm3, leukocytes ≥ 2000 /mm3 2. Total bilirubin ≤ 1,5 ULN, ASAT and ALAT ≤ 3 x ULN 3. Creatinine clearance ≥ 30 mL/min, verified proteinuria above or equal to 1g/24 hours measured from 24 hours of urine if the urinary protein 4. Corrected calcium ≤ ULN 7. Patient must have signed and dated informed consent 8. Patient must have an internet connection Exclusion Criteria: 1. Any contraindication to a ketogenic diet : primary carnitine deficiency, fatty acid beta-oxidation and cytogenesis deficiencies, pyruvate carboxylate deficiency, porphyria 2. Swallowing disorder 3. Important surgical procedure within the 4 weeks before treatment 4. Prior radiotherapy must have been completed at least 2 weeks prior to treatment 5. Pregnant women or breastfeeding 6. Subjects with previous malignancies (except non-melanoma skin cancer and the following endometrial in situ cancers) are excluded unless a complete remission was achieved at least 3 years prior to study entry and no additional therapy is required during the study period 7. Subjects with symptomatics brain metastases, uncontrolled compression of the spinal cord, carcinomatous meningitis, signs of cerebral or leptomeningeal involvement 8. Uncontrolled blood pressure (SBP \>150 mmH et DBP \>100 mmHg) 9. Any serious or uncontrolled medical disorder during the last 6 months : hepatic insufficiency, renal insufficiency, respiratory insufficiency 10. Patients with any severe medical conditions within 6 month prior to inclusion such as : myocardial infarction, severe/instable angina pectoris, coronary artery bypass surgery, NYHA III or IV congestive heart failure, stroke or transient ischemic attack 11. Patients with sere medical conditions within 3 month prior to inclusion such as : grade 3 or grade 4 gastrointestinal bleeding, peptic ulcer treatment resistant, esophagitis or ulcerated gastritis, infectious or inflammatory bowel disease, diverticulitis, thrombosis, pulmonary embolism or other uncontrolled thromboembolic event, unhealed bone fractures 12. Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) 13. Malabsorption syndrome 14. Uncontrolled infection 15. QT/QTc interval \> 450 msec for men and \> 470 msec for women 16. Concomitant treatments : strong inducers of CYP3A4 (DEXAMETHASONE, PHENYTOINE, CARBAMAZEPINE, RIFAMPICINE, RIFABUTINE, RIFAPENTINE, PHENOBARBITAL, and ST. JOHN'S WORT) 17. Social, psychological or medical condition that may interfere with participation in the study or its evaluation 18. Patient deprived of liberty by judicial or administrative decision 19. Patient with psychiatric treatment under duress 20. Patient subject to legal protection measures 21. Patient unable to give informed consent.