The aim of the study is to analyze cardiac biomarkers, electrocardiograms and cardio-pulmonary exercise test (CPET) results in children with cardiomyopathies.
The study group will consist of children that have been diagnosed with DCM, HCM or LVNC. The control group will be composed of healthy children. Examination of cardiac biomarkers (in the study group), ECG, 24-hour- ECG monitoring, CPET will be performed. Patients in the study group will be invited for 2 consecutive visits (in 6-10 months intervals). During the first and the last visit CPET will be performed. The control group will not be invited for consecutive visits.
Study Type
OBSERVATIONAL
Enrollment
80
ECG will be performed during each visit in the study group.
24-hour ECG monitoring will be performed during each visit in the study group.
CPET will be performed during the first and the last visit in the study group.
Medical Univeristy of Warsaw
Warsaw, Poland
Assessment of ECG (electrocardiographic) differences in children with cardiomyopathies and healthy children.
Assessment of heart rhythm, heart rate (BPM), PQ, QRS, QT, QTc intervals, QRS-T angle and arrythmia in ECG. These will be compared with arrythmia severity in 24-hour ecg monitoring.
Time frame: 14 months
Assessment of differences in CPET results in children with cardiomyopathies and healthy children.
Assessment of peak respiratory oxygen uptake (peakVo2), carbon dioxide production (Vco2), anaerobic threshold (AT), expired ventilation (VE), ventilatory equivalent for CO2 (VE/VCO2), VO2/Work rate relationship, maximal workload (W), duration of exercise (T).
Time frame: 14 months
Assessment of progression of heart failure in children with cardiomyopathies
Assessment of serum cardiac biomarkers (Troponin I, NT-proBNP) in children with cardiomyopathies during each visit.
Time frame: 20 months
Assessment of arrhythmia in time in children with cardiomyopathies
Assessment of heart rhythm, heart rate (BPM), PQ, QRS, QT, QTc intervals, QRS-T angle and arrythmia in ECG during each control visit. The results will be compared to the severity of arrythmia in 24-hour ecg monitoring. These test will be performed during each visit.
Time frame: 20 months
Assessment of changes in CPET results in children with cardiomyopathies
Assessment of peak respiratory oxygen uptake (peakVo2), carbon dioxide production (Vco2), anaerobic threshold (AT), expired ventilation (VE), ventilatory equivalent for CO2 (VE/VCO2), VO2/Work rate relationship, maximal workload (W), duration of exercise (T). CPET will be performed in during the first and the last control visit.
Time frame: 20 months
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Cardiac biomarkers will be assessed during each visit in the study group.