Predictors of Respiratory Failure in SARS-Cov-2 Infection

University of Bologna350 enrolled

Overview

The emergence of SARS-CoV-2 is currently engaging and consuming most of resources of efficient healthcare systems in Europe, and several hospitals are currently experiencing a shortage of ICU beds for critically-ill patients with SARS-CoV-2 pneumonia. A risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need ICU admission and/or those who may benefit from a prompt antiviral therapy

The study will compared patients with and without respiratory failure in order to find risk factors for need for ICU admission. A simple score based on risk factors will be created from a multicenter Italian cohort and validated in a multicenter international cohort.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

SARS-CoV-2 Pneumonia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hospitalized patients with microbiologically confirmed diagnosis of SARS-CoV-2 infection * Age \> 17 years Exclusion Criteria: * Invasive mechanical ventilation within 12 hours from hospital admission

Locations (1)

University of Bologna - Department of Medical and Surgical Sciences

Bologna, Italy

RECRUITING

Outcomes

Primary Outcomes

Respiratory failure

Composite of ICU admission or SpO2\<92% with 100% FiO2 of oxygen treatment (reservoir mask or CPAP or NIV), respiratory rate \>30 bpm, respiratory distress

Time frame: 14 days

Secondary Outcomes

Occurence of bacterial superinfection

Incidence of bacterial superinfection among ventilated patients with SARS-CoV-2 pneumonia

Time frame: 14 days

Data from ClinicalTrials.gov

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