the Association Between Obesity and Early Puberty

Shenzhen Center for Disease Control and Prevention628 enrolled

Overview

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Study Type

OBSERVATIONAL

Enrollment

628

Conditions

Early Puberty

Eligibility

Sex: FEMALEMin age: 7 YearsMax age: 10 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of central precocious puberty or early and fast puberty. Exclusion Criteria: * The participants who were not the first visit to the hospital and had been treated before. * The participants who were with endocrine disorders.

Outcomes

Primary Outcomes

genotypes of SNPs in the obesity-related genes

the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.

Time frame: 3 months

Data from ClinicalTrials.gov

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