Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart Failure

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: * Participants currently hospitalized for acute decompensated heart failure (ADHF) * Participants must be hemodynamically stable, as assessed by the investigator * Men must agree to follow specific methods of contraception, if applicable, while participating in the trial * Women participants must have documented proof that they are not of childbearing potential Exclusion Criteria: * Acute cardiovascular condition other than heart failure (HF) decompensation * Cardiogenic shock at presentation to emergency room (ER) or at any time before randomization * Recipient of ventricular assist devices or use of any cardiac extracorporeal devices, within 12 weeks of study randomization * Participants with contraindications to vasodilator therapy such as restrictive or obstructive cardiomyopathy, severe mitral or aortic stenosis Other protocol-defined inclusion/exclusion criteria apply