Non-Invasive Brain Stimulation

Chinese University of Hong Kong40 enrolled

Overview

The study focusses on utilizing neuroimaging modalities, including Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) to study the impact of non-invasive brain stimulation on the prefrontal cortex during a cognitive task.

In this study, a total of 40 subjects will be randomly assigned to 2 groups i.e. experimental and sham. Conventional transcranial direct current stimulation (c-tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) will be used to stimulate the prefrontal cortex of the brain. EEG and fMRI will be collected before, during and after stimulation to understand the impact of stimulation on brain dynamics. The investigators hypothesize that the stimulation of the prefrontal cortex will improve performance during cognitive tasks along with changes in the neural processing detected by neuroimaging modalities.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Stroke

Interventions

Transcranial Direct Current StimulatorDEVICE

Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation device that can excite or inhibit the brain activity depending on the stimulation protocol. It has mainly two variants including conventional c-tDCS and High-Definition HD-tDCS.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Right Handedness, * Age \> 18 Exclusion Criteria: * History of any other neurological disease, * Any psychological or psychiatric disease, * Significant visual or auditory impairments, * tDCS contraindications including implanted metallic or electronic devices, seizures or convulsions, and pregnancy.

Locations (1)

Department of Biomedical Engineering, The Chinese University of Hong Kong

Shatin, Hong Kong

RECRUITING

Outcomes

Primary Outcomes

Reaction Time (RT)

Reaction time of the subject during a cognitive task would be a measure to assess changes in performance due to stimulation

Time frame: 1 hour

Concentration Rate

The percentage of accurate responses during the cognitive task within the stipulated time will be calculated to see an impact on concentration after stimulation

Time frame: 1 hour

Event related potential latency and amplitude

Changes in latency and amplitude of event related potentials including P300 \& N200 would be used as neural marker to understand cognitive processing in the brain.

Time frame: 1 hour

Functional Magnetic Resonance Imaging (fMRI)

Changes in fMRI connectivity

Time frame: 1 hour

Central Contacts

Raymond Tong, PhD

CONTACT

+852 3943 8454 kytong@cuhk.edu.hk

Data from ClinicalTrials.gov

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