The overall purpose of this project is to better understand the incidence, risk factors, etiology, clinical manifestations and outcome of tCOVID19 in solid organ transplant recipients. The results obtained will allow us to gain insight on the need of antiviral treatment, on the strategy for complications surveillance, on how to adjust the immunosuppressant therapy and on the level of care in which each patient should be treated. In order to attain the objectives previously described we will develop a multicenter prospective study of consecutive cases of COVID-19 among solid organ transplant recipients.
There will be a clinical follow-up of the patients included in this study to observe possible complications and survival rate. Data collected form this study will be evaluated with a descriptive statistical analysis of the cohort consisting of analysis of the risk factors of COVID-19. Subsequently a multivaried logistic regression analysis will be performed in which the factors selected from the analysis and those clinically relevant.
Study Type
OBSERVATIONAL
Enrollment
488
Hospital Universitario Virgen del Rocio
Seville, Spain
Incidence of coronavirus infection in Solid Organ Transplant Recipients
Number of Solid Organ Transplant Recipients positive to coronavirus
Time frame: From baseline at the time of signature of informed consent form to day 28 after confirmation of positive test to coronavirus
Clinical manifestations of coronavirus infection in Solid Organ Transplant Recipients
Number of participants who present clinical symptoms possibly related to coronavirus infection in Solid Organ Transplant Recipients
Time frame: From baseline at the time of signature of informed consent form to day 28 after confirmation of positive test to coronavirus
Presence of other risk factors
Gathering possible risk factors in coronavirus infection in Solid Organ Transplant
Time frame: From baseline at the time of signature of informed consent form to day 28 after confirmation of positive test to coronavirus
Establish the frequency and type of complications related to the net state of the patient immunosuppression
Establish the frequency and type of complications related to the net state of the patient immunosuppression
Time frame: From baseline at the time of signature of informed consent form to day 28 after confirmation of positive test to coronavirus
Frequency of co-infections
Another infections at the time of coronavirus positive infection will be gathered
Time frame: From baseline at the time of signature of informed consent form to day 28 after confirmation of positive test to coronavirus
Mortality
Number of deaths caused or complicated by coronavirus infection in patients who has recceived Solid Organ Transplant
Time frame: From baseline at the time of signature of informed consent form up to study completion at 3 months folllow-up
Laboratory characteristics
Biochemical analysis, hemogram,
Time frame: At inclusion and at 28 days of follow up
Determination of coronavirus viral load
Nasopharyngeal swabs
Time frame: At inclusion at 14 days and at 28 days
Microbiological testing
According to the clinical manifestations at blood culture, pleural liquid culture, gram stain and culture of sputum, detection of pneumococcus and Legionella pneumophila antigen in urine, in cases of pneumonia
Time frame: At inclusion at 14 days and at 28 days
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