Lenvatinib Following Liver Transplantation in Patients of Hepatocellular Carcinoma With Portal Vein Tumor Thrombus

Inclusion Criteria: 1. Patients who underwent liver transplantation were preoperatively imaging diagnosed as hepatocellular carcinoma with portal vein tumor thrombus. 2. Male or female patients aged 18 to 75. 3. ECOG physical condition was 0-2 points. 4. Child-Pugh A grade of liver function. 5. Targeted therapy is acceptable within 1-2 months after liver transplantation. 6. Immunosuppressive regimen consists of calcineurin inhibitor, mycophenolate mofetil and sirolimus. 7. No history of surgical resection of liver tumors and targeted drug therapy before liver transplantation. 8. Good liver, kidney and bone marrow function: serum albumin \> 28g/L, total bilirubin ≤ 3 mg/dL (51.3 umol/l), ALT and AST ≤ 5 times the upper limit of normal range; serum creatinine ≤ 1.5 times the upper limit of normal range; hemoglobin \> 90 g/L, neutrophil count (ANC) \> 1.5 \* 10 \^ 9/L, platelet count \> 60 \* 10 \^ 9/L; PT-INR \< 2.3, or PT within 6 seconds over normal upper limit. 9. For fertile female patients, the serum/urine pregnancy test should be negative within 7 days before treatment. 10. All male and female participants must take reliable contraceptive measures during the trial and within four weeks after the end of the trial. 11. The participants have the capability of oral medication. 12. The participants must sign the consent form. Exclusion Criteria: 1. Hepatocellular carcinoma with invasion of hepatic vein and inferior vena cava 2. Life expectancy is less than 3 months 3. The recurrence and metastasis of hepatocellular carcinoma are highly suspected. 4. Patients are with other malignant tumors simultaneously. 5. Patients are anaphylaxis to the inactive ingredients of lenvatinib or drugs. 6. Pregnant or lactating women (Female participants need pregnancy test within 7 days before treatment). 7. Preoperative history of severe cardiovascular disease: congestive heart failure \> NYHA grade 2; active coronary heart disease (myocardial infarction occurred within 6 months before entry into the study); severe arrhythmia requiring antiarrhythmic treatment (allowable use of beta-blockers or digoxin); uncontrolled hypertension. 8. History of HIV infection. 9. Severe clinical active infections (\> NCI-CTCAE version 3.0). 10. Epilepsy patients requires medication (e.g. steroids or antiepileptic drugs). 11. Patients with kidney diseases requires renal dialysis. 12. Drug abuse, medical symptoms, mental illness or social status that may interfere with participants'participation in research or evaluation of research results. 13. Patients who could not swallow oral drugs, such as those with severe upper gastrointestinal obstruction and need gastric tube feeding. 14. Other anti-angiogenesis therapies, surgery, TACE, local therapy and systemic chemotherapy were given before the treatment after liver transplantation.