Postoperative surveillance of local metabolism of the surgical reconstruction after esophagectomy by means of Microdialysis. Dialysate is collected continuously for seven postoperative Days. Results analysed in a blinded fashion and related to the clinical outcome. Primary endpoint: anastomotic leakage
The purpose of the study is to evaluate Onzurf probe (microdialysis probe) as a monitoring method for the early diagnosis of complications after surgery in the gastrointestinal tract. Samples taken with Onzurf probe will be analyzed and then compared with routine clinical data on surgical procedures in gastrointesinala tract. These parameters are: Patient general condition, endoscopy, radiology and routine clinical samples (global) as CRP (C-reactive protein), white blood cells, blood gases.The patients are their own controls when the purpose is to see if you can detect early complications with Onzurf probe and also identify how many people gets complications after surgery in the gastrointestinal tract. The patients' clinical routine tests (blood tests, etc.) will serve as control samples, which then will be compared with results from sampling of Onzurf probe. No interventions will be carried out on the patient.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
60
Skånes Universitetssjukhuset
Lund, Skåne County, Sweden
Concentration of lactate measured by microdialysis in patients with anastomotic leakage as defined by endoscopy or radiology
Concentration in millimoles / liter of lactate measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of lactate measured by microdialysis in patients with a normal uncomplicated postoperative recovery
Concentration in millimoles / liter of lactate measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of glucose measured by microdialysis in patients with anastomotic leakage as defined by endoscopy or radiology
Concentration in millimoles / liter of glucose measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of glucose measured by microdialysis in patients with a normal uncomplicated postoperative recovery
Concentration in millimoles / liter of glucose measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of pyruvate measured by microdialysis in patients with anastomotic leakage as defined by endoscopy or radiology
Concentration in millimoles / liter of pyruvate measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of pyruvate measured by microdialysis in patients with a normal uncomplicated postoperative recovery
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Concentration in millimoles / liter of pyruvate measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of glycerol measured by microdialysis in patients with anastomotic leakage as defined by endoscopy or radiology
Concentration in millimoles / liter of glycerol measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days
Concentration of glycerol measured by microdialysis in patients with a normal uncomplicated postoperative recovery
Concentration in millimoles / liter of glycerol measured repeatedly (see below) to produce a metabolic profile over time
Time frame: Measured with four hour intervals during the first seven postoperative days