The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Nelutri™on muscle strength, muscle mass, and muscle function in healthy adults for 12 weeks.
A previous study has indicated that Nelutri™ may increase muscle mass and strength. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Nelutri™on muscle strength, muscle mass, and muscle function in healthy adults; the safety of the compound are also evaluate. The Investigators examine the peak torque/body weight at 60°/s knee extension, handgrip strength, skeletal muscle mass, physical performance, and metabolic parameters at baseline, as well as after 6 and 12 weeks of intervention. Eighty adults were administered either 2,000 mg of Nelutri™ or a placebo each day for 12 weeks;
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
80
Nelutri™ 2,000 mg/day for 12 weeks
Placebo 2,000 mg/day for 12 weeks
Pusan National University Yangsan Hospital
Yangsan, Gyeungsangnam-do, South Korea
muscle strength
the peak torque at 60°/s knee extension (/kg)
Time frame: 12 weeks
appendicular skeletal mass/(height x height)
using dual-energy X-ray absorptiometry
Time frame: 12 weeks
appendicular skeletal mass/weight x 100
using dual-energy X-ray absorptiometry
Time frame: 12 weeks
Skeletal Muscle Mass Index/(height x height)
using dual-energy X-ray absorptiometry
Time frame: 12 weeks
Creatinine Kinase
Creatinine Kinase
Time frame: 12 weeks
Lactate
Lactate
Time frame: 12 weeks
EuroQol five dimensional three levels (EQ-5D-3L)
an index of life quality, minimum, maximum values (-0.171, 1), higher scores mean a better outcome
Time frame: 12 weeks
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