The purpose of this study is evaluate the effect of Nitroglycerin paste on wound healing and scarring. Previous research has shown that Nitroglycerin paste can improve the blood flow to a wound, which may be associated with better wound healing, and ultimately, better scarring.
This will be a single-center, patient-blinded, (breast) randomized trial utilizing nitroglycerin paste on their breast reduction scar. The study team aims to randomize 100 patients, or 200 breasts. Each patient will receive treatment, but the breast that received treatment will be random. This will allow for a control breast to compare to. Patients will be followed for 12 months postoperatively to observe wound healing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
1g of 2% Nitroglycerin paste topical application
Topical skin adhesive
Mount Sinai Hospital
New York, New York, United States
Change in Vancouver Scar Scoring (VSS)
Change in Vancouver Scar Scoring at 12 as compared to first post visit. VSS is a standardized scar appearance protocol - full score from 0-13, with higher score indicating poorer health outcomes.
Time frame: First post-op visit (0 weeks post op) and last visit at 12 months
Number of occurrences of wound breakdown
Change in number of occurrence of necrosis and/or wound breakdown at 12 months as compared to the first post-op visit
Time frame: 12 months
Number of side-effects of Nitroglycerin use
Side effects of nitroglycerine use measured as a composite of side effects which includes pre-syncope, syncope, chest pains and headache.
Time frame: 12 months
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