The purpose of this study is to investigate effects of foliglurax on brain wave patterns (electric signals) in healthy subjects and in patients with PD
All Treatment Periods (P1 to P3) consist of 7 days of dosing (D1 to D7) with either: * 10 mg foliglurax bis in die (BID) (treatment A) * 30 mg foliglurax BID (treatment B) * Placebo BID (treatment C)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
6
Foliglurax 10 mg, (BID) capsules, orally
Foliglurax 30 mg, BID capsules, orally
Placebo, BID capsules, orally
Biotrial Rennes
Rennes, France
Latency of EEG movement related desynchronization of the μ-oscillations
Latency of μ-desynchronization ipsilateral and contralateral (in ms)
Time frame: From baseline to Day 7 in each Treatment Period
Latency of EEG movement related synchronization of the beta-oscillations
Latency of beta-rebound ipsilateral and contralateral (in ms)
Time frame: From baseline to Day 7 in each Treatment Period
Offset of EEG movement related synchronization of the beta-oscillations
Offset of beta-rebound ipsilateral and contralateral (in ms)
Time frame: From baseline to Day 7 in each Treatment Period
Latency of movement from cue measured by accelerometer
Latency of movement from cue (in ms)
Time frame: From baseline to Day 7 in each Treatment Period
Average power in u-desynchronization cluster measured by EEG
Power in μ-desynchronization cluster ipsilateral and contralateral (in micro-volts squared)
Time frame: From baseline to Day 7 in each Treatment Period
Average power in beta-rebound cluster measured by EEG
Power in beta-rebound cluster ipsilateral and contralateral (in micro-volts squared)
Time frame: From baseline to Day 7 in each Treatment Period
Power in the frequency domain of the greater tremor frequency
Power in micro-volts squared
Time frame: From baseline to Day 7 in each Treatment Period
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