This study aims to explore the efficacy and safety of Crizotinb or Standard Chemotherapy in Met exon 14 skipping Advanced Non-small Cell Lung Cancer
This study aims to explore the efficacy and safety of Crizotinb or Standard Chemotherapy in Met exon 14 skipping Advanced Non-small Cell Lung Cancer . All the clinical and survival data will be collected for full analysis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Crizotinib 250mg po bid. Savolitinib 300mg po, qd.
Pemetrexed, 500mg/m2, ivgtt erery 21day.
Yongchang Zhang
Changsha, Hunan, China
RECRUITINGProgression-free survival (PFS)
PFS defines as first dose to first documented disease progression assessed by investigator or death due to any cause
Time frame: Time from first subject dose to study completion, or up to 36 month
Overall survival (OS)
To assess overall survival, define as first dose to the death of the subject due to any cause
Time frame: Time from first subject dose to study completion, or up to 36 month
Objective Response Rate (ORR)
To assess Chemotherapy and TKIs overall response rate according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 by investigator, define as the proportion of subjects who have a complete response (CR) or a partial response (PR)
Time frame: Time from first subject dose to study completion, or up to 36 month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.