In liver cirrhosis (LC),the activity of von Willebrand factor (vWF)-cleaving enzyme ADAMTS13 is reduced in LC patients and consequent progression of liver injury. Remarkably, it has been reported that a severe vWF/ADAMTS13 imbalance develops during liver transplantation (LT) and persists even after LT. Such changes are thought to contribute to postoperative thrombotic complications, which may lead to early adverse events of thrombotic microangiopathy after living-donor LT (LDLT). We investigated whether vWFPCR could predict EAD or graft failure following LT and compared it with FVIIIPCR, procoagulant, such as vWF and FVIII and anticoagulant, such as PC.
Study Type
OBSERVATIONAL
Enrollment
1,199
Liver transplantation
Asan Medical center
Seoul, South Korea
Early allograft dysfunction
Immediate liver graft function
Time frame: within 7 days after surgery
Graft failure
re-liver transplantation or death, whichever was first
Time frame: 90 days
intensive care unit stay
days of intensive care unit stay after liver transplant
Time frame: until the day of patients moving to general wards, through study completion, an average of 1 year
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