Study of Eye Movements as Markers of the Physiological, Cerebral and Cognitive State of Healthy Subjects

University Hospital, Grenoble45 enrolled

Overview

The goal of this study is the multimodal exploration via eyetracking, MRI and EEG data of ocular movements and the corresponding brain activation during ecologic visual stimulation in the healthy population.

Cerebral activation following visual stimulation is explored using two neuroimaging techniques EEG and MRI while eye movements are recorded. Three experiments are performed: in MR scanner 1) functional localisation of specific areas: LOC, FFA, MT/V5, V1 and V2 and 2) a saccadic choice experiment; with EEG, replication of the experiments performed in the MR scanner and 3) an additional experiment of movement detection during the ocular saccades. Thirty young volunteers (18-40 y old) are involved.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

NeuroimagingOTHER

MR, EEG recordings

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal vision or corrected to normal * Social security affiliation * Signed consent to participate * No pregnancy fo women Exclusion Criteria: * Audition and motor troubles * Incapable to decide (Persons mentioned in L1121-5,6 et 8 of public health code) * Neurological disorders * Pathology affecting oculomotor control * MRI incompatibility

Locations (1)

Chu Grenoble Alpes

Grenoble, France

Outcomes

Primary Outcomes

Eye movement brain networks

Identification of the cerebral locus of ocular movement via MRI \& EEG

Time frame: 24 months

Secondary Outcomes

OculoDB

Database repository of healthy population

Time frame: 24 months

Data from ClinicalTrials.gov

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