The Utility of Breath Biopsy as a Screening Tool for HCC

University of Aberdeen18 enrolled

Overview

The aim of this pilot study is to examine whether there is a discriminating ability of the breath sample analysis to capture biomarkers specific to the HCC in the breath of affected individuals. If positive, our research could open up a new horizon for cost-effective and feasible screening tools.

20 Participants will be included in the study. Ten Cirrhotic patients with HCC and 10 Cirrhotic patients without HCC. The first group is patients with HCC secondary to cirrhosis. The second group will be patients with cirrhosis who are currently on the standard surveillance program with no HCC. Confirmation of the absence of HCC would have been ensured via a recent advanced imaging modality (dynamic CT scan or MRI) in the ongoing surveillance programme. Participants will breathe into either a mouthpiece or collection tube then Breath samples will be analyzed via an analyzer to detect the volatile organic compounds (VOC) and quantitatively compare them

Study Type

OBSERVATIONAL

Enrollment

Conditions

HCC Cirrhosis, Liver

Interventions

Breath BiopsyDIAGNOSTIC_TEST

Analysis of breath samples to identify volatile molecules specific to HCC

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cirrhotic patients with HC. * Cirrhotic patients without HCC Exclusion Criteria: * Patients with more than one primary cancer (HCC in addition to other cancer) * Patients who are not aware of the diagnosis * Patients in whom the diagnosis of HCC is not clear and only suspected * Patients with severe chronic obstructive pulmonary disease (COPD) or severe asthma.

Locations (1)

Ashis Mukhopadhya

Aberdeen, United Kingdom

Outcomes

Primary Outcomes

Volatile organic compounds specific to HCC

Quantitative analysis of the volume and pattern of volatile compounds in the breath of the individuals with HCC compared to that in the breath of individuals without HCC but with the same underlying disease

Time frame: 6 months

Data from ClinicalTrials.gov

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