Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis

First Affiliated Hospital of Harbin Medical University129 enrolled

Overview

This study aims to evaluate ocular changes in patients with carotid artery stenosis by optical coherence tomography angiography before and after carotid artery revascularization procedure.

A growing body of research indicates that abnormal ocular microvascular features may serve as a novel biomarker reflecting the severity of underlying cardiovascular, neurodegenerative, and microvascular disease. Since blood flow to the retina is predominantly supplied by the internal carotid artery (ICA), we hypothesized that ocular microvasculature and structure changes may reflect the disease status or therapeutic effects in patients with carotid artery stenosis. Optical coherence tomography angiography (OCTA) is a novel, non-invasive imaging modality that can be a reliable tool for the qualitative and quantitative assessments of ocular vessels during various ocular pathological or physiological changes. Recent studies have also demonstrated the ability of OCTA to quantify retinal microvascular changes in monitoring cardiovascular risk. This study aims to evaluate ocular changes in patients with carotid artery stenosis by optical coherence tomography angiography before and after carotid artery revascularization procedure.In this study, the patients with carotid artery stenosis and control group will receive a series of cerebral and ocular examinations including the most important cerebral CT perfusion (CTP) and OCTA. After that, the cerebral and ocular data between the two groups will be compared. Also, the preoperative and postoperative data acquired will be compared.

Study Type

OBSERVATIONAL

Enrollment

129

Conditions

Carotid Stenosis

Interventions

Carotid artery revascularization procedurePROCEDURE

The patients with carotid artery stenosis will be examined before and after finishing the carotid artery revascularization procedure.

Optical coherence tomography angiographyDEVICE

Examination will be performed using optical coherence tomography angiography. This device allows quantitative analysis, since it provides numerical data about flow area and flow density maps.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of carotid artery stenosis * Age-gender-race-matched controls Exclusion Criteria: * age \<18 years * intraocular pressure (IOP) \>21 mmHg * VA \>logMAR 1.0 * spherical equivalent (SE) between \>1.00 or \< -6.00 D * other serious eye diseases which may affect OCTA results including diabetic retinopathy, hypertensive retinopathy, retinal vascular occlusion, age-related macular degeneration, and uveitis * major intraocular surgery performed in the past 6 months or a history of laser photocoagulation or intravitreal injection * glaucoma or first-degree relatives with a history of glaucoma; and * any disease that might cause poor scan quality (image quality \<6).

Locations (1)

The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

Outcomes

Primary Outcomes

Radical Peripapillary Capillaries Vessel Density

Radical peripapillary capillaries vessel density of Optical Coherence Tomography Angiography（OCTA）

Time frame: Difference of vessel density in each group at baseline

Superficial Vascular Complexes Vessel Density

superficial vascular complexes vessel density of Optical Coherence Tomography Angiography

Time frame: Difference of vessel density in each group at baseline

Deep Vascular Complexes Vessel Density

deep vascular complexes vessel density of Optical Coherence Tomography Angiography

Time frame: Difference of vessel density in each group at baseline

Choriocapillaris Vessel Density

choriocapillaris vessel density of Optical Coherence Tomography Angiography

Time frame: Difference of vessel density in each group at baseline

Secondary Outcomes

Change of Difference of Mean Transit Time(dMTT)

Change of dMTT is the dMTT value at 4 days after carotid artery procedure minus the value at baseline. dMTT is that the value of the lesion side minus value of contralateral side. Mean transit time (MTT) corresponds to the average time, in seconds, that red blood cells spend within a determinate volume of capillary circulation.

Time frame: baseline and 4 days after carotid artery procedure

Change of the Ratio of Cerebral Blood Flow(rCBF)

Change of rCBF is the rCBF value at 4 days after carotid artery procedure minus the value at baseline. rCBF is that the CBF value of the lesion side divided by the value of contralateral side. CBF refers to the flow of blood through a certain cross-sectional area of cerebrovascular per unit time.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.