Coronavirus 2019 (COVID-19) is a respiratory tropism virus transmitted through droplets emitted into the environment of infected persons. The symptoms can be extremely varied and the course can range from spontaneous healing without sequelae to death. Currently, the diagnosis of certainty for resuscitation patients (by definition "severe") is based on searching for a fragment of virus genetic material within the epithelial cells of the respiratory tree, up and/or down, by PCR. It is to be expected that the epidemic peak will make it difficult (if not impossible) to respect the stereotypical path that is currently in place, due to the lack of space in the specific unit. This will require optimization of care pathways and use of the specific sectors. It is therefore necessary to define the simple criteria, available from the moment patients are admitted, to predict the result of the COVID-19 PCR.
Study Type
OBSERVATIONAL
Enrollment
368
Hôpital Roger Salengro, ICU, CHU Lille
Lille, France
Correlation between nasal and deep PCR positivity for Covid-19 patients performed and all predictors for Covid-19 patients performed within 24 hours of admission to ICU
Time frame: within 24 hours of admission to ICU
Coinfections
Assessment of viral, bacterial, fungal and parasitic rate in confirmed and unconfirmed patients for COVID-19
Time frame: during ICU stay, up to 28 days
Respiratory dysfunction requiring mechanical ventilation
it will be reported the evolution of respiratory dysfunction in patients infected with COVID-19 admitted to ICU during their stay and requiring mechanical ventilation (during, Pao2/FIO2 ratio,,features of artificial ventilation features of extra-bodied respiratory assistance)
Time frame: during ICU stay, up to 28 days
Sequential Organ Failure Assessment (SOFA) Score
the SOFA assessment is used to track a person's risk status during stay in the Intensive Care Unit (ICU). The score is based on six different scores, one each for the respiratory, cardiovascular, hepatic, coagulation, renal, and neurological systems. Each organ system is assigned a point value from 0 (normal) to 4 (high degree of dysfunction/failure).
Time frame: during ICU stay, up to 28 days
SAPS II score
APS II was designed to measure the severity of disease for patients admitted to Intensive care units 24 hours after admission to the ICU, the measurement has been completed and resulted in an integer point score between 0 and 163 and a predicted mortality between 0% and 100%.
Time frame: at admission
Disseminated Intravascular Coagulation (DIC) score
The DIC Score was developed by the The International Society of Thrombosis and Haemostasis (ISTH.) The DIC score calculator accounts of the following four parameters.Each of the four parameters evaluated above have values that are weighted with a number of points varying from 0 to 3. By summing the points given to the choices, a final result between 0 and 8 is obtained
Time frame: during ICU stay, up to 28 days
Number of days on vasopressive amines
Time frame: during ICU stay, up to 28 days
Occurrence of an event of venous or arterial thromboembolic disease
Time frame: during ICU stay, up to 28 days
Number of days with extra renal treatment (ERA)
Time frame: during ICU stay, up to 28 days
Number of patients alive after ICU stay less than 28 days will be tracked
Time frame: At 28 day
Short Form 36
measuring the long-term impact of confirmed COVID-19 infection. assessment of quality of life according to 8 areas: physical activity (and related limitations), body pain, perception of one's own health, mental health (and related limitations), social life and vitality.
Time frame: at 9 months +/- 3 months after ICU stay
Hospital anxiety and depression scale (HADS)
The scale allows to detect anxiety and depression using 14 items rated from 0-3. Measuring the long-term impact of confirmed COVID-19 infection
Time frame: at 9 months +/- 3 months after ICU stay
Impact of Event Scale - revised (IES-R)
22-item self-report measure that assesses subjective distress caused by traumatic events Items are rated on a 5-point scale ranging from 0 ("not at all") to 4 ("extremely"). The IES-R yields a total score (ranging from 0 to 88) Measuring the long-term impact of confirmed COVID-19 infection
Time frame: at 9 months +/- 3 months after ICU stay
Post-traumatic stress disorder Checklist version DSM-5 (PSL-5)
Question the stressful experience or event, followed by 20 multiple-choice questions. Measuring the long-term impact of confirmed COVID-19 infection
Time frame: at 9 months +/- 3 months after ICU stay
Modified Medical Research Council (MMRC) Dyspnea Scale
The mMRC Dyspnea Scale stratifies severity of dyspnea in respiratory diseases Measuring the long-term impact of confirmed COVID-19 infection
Time frame: at 9 months +/- 3 months after ICU stay
Correlation between number of patient deaths and all predictors for Covid-19 including anamnestic, clinical, biological, radiological parameters
Time frame: until day 28 after admission of ICU
Viral clearance
Evolution of viral clearance in nasal and depp PCR during ICU
Time frame: through study completion, an average of 28 days
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