Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).
Background Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined. Objective The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort. Methods Cross-sectional association study in a cohort of non-cardiac surgery patients. This study is a Subproject of a prospective cohort study registered under the ID 041/09.
Study Type
OBSERVATIONAL
Enrollment
437
Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
Bern, Switzerland
Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels
Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels
Time frame: Blood samples collected at start of anesthetic procedure
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