Women with androgen excess polycystic ovary syndrome (AE-PCOS) leads to hypertension.
Our scientific premise is that in AE-PCOS women, the androgen-dominant hormonal milieu causes BP increases via sympathetic activation, vasoconstriction and renal sympathetic nervous system activation. Moreover, this androgen-dominant milieu increases BP via activation of the renin-angiotensin system.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
28
GnRH antagonist up to 16 days.
GnRH antagonist + MethylTESTOSTERone 5 MG up to 5 days.
The John B Pierce Laboratory
New Haven, Connecticut, United States
Baroreflex Response to LBNP
forearm blood flow (ultrasound)/mean arterial pressure as a linear function of lower body negative pressure. This is an important measure of autonomic control of blood pressure. Indicating the the sensitivity of changes in vessel diameter in response to blood pooling (induced by lower body negative pressure).
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Free Plasma Testosterone Levels
Concentration of testosterone in blood.
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Renal Response to LBNP
POST Lower body negative pressure Plasma renin activity
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Renal Responses to LBNP
PRE lower body negative pressure Plasma renin activity
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Resting Systolic Blood Pressure
Blood pressure prior to lower body negative pressure
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Final Systolic Blood Pressure
SBP at the end of lower body negative pressure
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Resting Sympathetic Activity
Total sympathetic nerve activity
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
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Sympathetic Baroreflex
microneurography, diastolic blood pressure (finipres) This is an important measure of autonomic control of blood pressure. Indicating the the sensitivity of changes in muscle sympathetic nerve activity in response to small changes in blood pressure induced by drug perfusion (modified Oxford).
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Aldosterone
Plasma aldosterone concentration
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone
Renal Responses
P\[ACE\], angiotensin-converting enzyme
Time frame: Baseline, assessed at 7 days of GnRH, assessed at 16 days GnRH+ 5 days of Testosterone