L-citrulline is found naturally in watermelon. Recently interest has increased for this amino acid due to potential health benefits. Notably, L-citrulline has the potential to lead to dilation of blood vessels due to its involvement in the production of nitric oxide. The study will be an acute single blind, randomised controlled, crossover intervention study in healthy, young volunteers. Participants receive either the test watermelon drink or control drink (water). Blood samples and vascular measures (by a single-cuff based method) will be measured at baseline. Vascular measures will be repeated at 15-minute intervals between 0-2 hours and a second blood sample will be drawn at 1.5 hours to coincide with the estimated peak plasma L-citrulline. Citrulline, arginine and nitric oxide metabolites will be measured in the blood samples.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
10
500 mL watermelon juice (What a Melon), containing \~1 g of L-citrulline.
500 mL low nitrate water
University of Reading
Reading, UK, United Kingdom
Change in blood pressure
Blood pressure by automated device
Time frame: At baseline (t= 0 hours) and 15 minute intervals until t= 2 hours.
Change in NOx (nitric oxide metabolites)
Plasma nitrate and nitrite concentration
Time frame: At baseline (t= 0 hours) and t=1.5 hours.
Change in l-arginine
L-arginine concentration
Time frame: At baseline (t= 0 hours) and t=1.5 hours.
Change in l-citrulline
L-citrulline concentration
Time frame: At baseline (t= 0 hours) and t=1.5 hours.
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