Mutation of the LEPR Gene at Reunion Island: Involvement in Pediatric Obesity

Centre Hospitalier Universitaire de la Réunion250 enrolled

Overview

The objective of this study is to estimate the proportion of the recurrent deletion Δ6-8 of the LEPR gene in the homozygous and heterozygous state in pediatric cases with severe and early ( before the age of 6) obesity (BMI ≥ IOTF-30) on Reunion Island.

The study of the deletion Δ6-8 of the LEPR gene starts with a saliva sample using a swab in children aged between 3 to 18 years old. The DNA from this sample will then be analyzed by the PCR technique. If the deletion of the LEPR gene is confirmed in the patient, his adult family members will also be screened using the same procedure.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Obesity, Childhood

Eligibility

Sex: ALLMin age: 3 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient with early severe and non syndromic obesity (BMI\> IOTC-30) (before 6 years old) * adult family members with deletion of LEPR gene * informed consent form signed by participants or parents * affiliation to social security scheme Exclusion Criteria: * patient with syndromic obesity * patient Under guardianship or Under judicial protection

Outcomes

Primary Outcomes

Proportion of the Δ6-8 deletion of the LEPR gene in paediatric population

Presence of the deletion of the LEPR gene

Time frame: at inclusion

Secondary Outcomes

Proportion of the Δ6-8 deletion of the LEPR gene in adult family members

Presence of the deletion of the LEPR gene

Time frame: 6 months after inclusion of the paediatric population

Central Contacts

Emilie TECHER

CONTACT

+262 262 90 62 89 emilie.techer@chu-reunion.fr

Data from ClinicalTrials.gov

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