Cambridge 7 Tesla Cerebral Small Vessel Disease Study

University of Cambridge210 enrolled

Overview

CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.

Study Type

OBSERVATIONAL

Enrollment

210

Conditions

Cerebral Small Vessel Diseases Cerebral Small Vessel Ischemic Disease Lacunar Stroke

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\. Symptomatic lacunar stroke with corresponding lacunar infarct on MRI Exclusion Criteria: 1. Unable/unwilling to consent; 2. Age\<18; 3. Stroke aetiology due to cardio-embolism or large vessel disease; 4. Lacunar infarcts \>1.5cm; 5. Severe stroke (NIHSS score ≥16); 6. Evidence of cortical infarct of any size; 7. Other major neurological diseases; 8. Severe systemic diseases such as heart failure, liver failure and kidney failure or any illness in the judgement of the investigator that could affect participation in the study; 9. MRI contraindications e.g. metal objects in or on the body, claustrophobia, pregnancy, known allergy to gadolinium containing contrast agent, impaired renal function with estimated glomerular filtration rate (eGFR) \<59ml/min/1.73m2.

Outcomes

Primary Outcomes

Range and pattern of pathology seen in the perforating arteries like presence or absence of focal atheroma and narrowing

Time frame: March 2020-

Secondary Outcomes

Differences in morphology of perforating arteries between SVD patients and healthy volunteers

Time frame: March 2020-

Correlation of morphology of perforating arteries with cardiovascular risk factors and radiological markers of SVD

Time frame: March 2020-

Central Contacts

Stefania Nannoni, MD

CONTACT

01223 216 509 sn572@medschl.cam.ac.uk

Christopher Osuafor, MBBS

CONTACT

01223 274 383 co400@cam.ac.uk

Cambridge 7 Tesla Cerebral Small Vessel Disease Study

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts