Normal Ventilatory and Perfusion Pulmonary Function in TEMP

University Hospital, Brest96 enrolled

Overview

Ventilation - perfusion SPECT is attractive for lung function assessement. Unfortunately, it is very difficult to delineate normal to abnormal areas because of physiological uptake heterogeneity. In that context, it would be of interest to build statistical maps from registrered normal studies and propose a new methodology for normal SPECT delineation

Patients with normal VQ SPECT-CT will be analysed. After a image proccesing workflow including rigid registration, non rigid registration and normalization, a voxelized mean and standard deviation map will be created. Those maps will be analyzed in regards of physiology and litterature.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Patents With Normal VQ/SPECT

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * normal perfusion and ventilation scans, and no parenchyma or pleural abnormality on low dose CT * confirmation by a second senior physician Exclusion Criteria: Patients with history of pulmonary disease: * chronic obstruction pulmonary disease, * previous pulmonary embolism, * surgery of the lungs * radiotherapy of the lungs

Locations (1)

Médecine nucléaire - Hôpital Morvan (CHRU de Brest)

Brest, France

Outcomes

Primary Outcomes

Posterior to Anterior and Inferior to Superior uptake relative difference on parametric mean registered SPECT map versus non registered SPECT

parametric mean and standard deviation maps are build from elastic registration of normal lung V/Q SPECT-CT. A ROI based quantitative regional uptake comparison is performed to verify the influence of elastic registration on radiotracer distribution

Time frame: through study completion, an average of 3 months

Data from ClinicalTrials.gov

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