Background: Patients with cirrhosis and acute-on-chronic liver failure (ACLF) may have bleeding complications which can lead to increased mortality. Standard coagulation tests (SCTs) like prothrombin time, platelet count and activated partial thromboplastin do not accurately depict in vivo coagulation profile. Point-of-care viscoelastic coagulation testing devices like thrombo-elastography (TEG) and Sonoclot may be better for guiding patient management. Methods: This prospective observational study compared and validated the point of care (POC) tests and SCTs in 70, 72 and 25 persons with ACLF, decompensated cirrhosis and healthy controls respectively.
Study Type
OBSERVATIONAL
Enrollment
142
PGIMER
Chandigarh, India
Validation of TEG and Sonoclot
To clinically validate the comparibility of results obtained from the TEG and Sonoclot instruments
Time frame: Day 3
Correlation of Point of care test with standard coagulation tests
To investigate whether variables from TEG or Sonoclot analyses correlated with Standard Coagulation Tests
Time frame: Day 3
Correlation of Point of care tests with bleeding event
To assess whether a coagulation defect on TEG or Sonoclot predicts a bleeding event or not.
Time frame: Day 28
Correlation of Point of care tests with mortality
To assess whether a coagulation defect on TEG or Sonoclot predicts mortality
Time frame: 28 days
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