Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

Miguel Ayala León21 enrolled

Overview

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory. The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glycocalyx Cardio-Renal Syndrome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Over 18 years of age * Patients who underwent cardiac surgery for a single valve change or replacement Exclusion Criteria: * Stage 3 renal failure patients * Patients with a previous diagnosis of hematological malignancy * Patients undergoing pulmonary valve change surgery. * Patients undergoing Bentall and Bono surgery. * Patients Undergoing Coronary Artery Bypass Surgery

Locations (1)

Outcomes

Primary Outcomes

Extracorporeal circulation time

Duration of Extracorporeal Circulation in minutes

Time frame: 2 hours

Aortic clamping time

Duration of aortic clamping time in minutes

Time frame: 2 hours

Hyaluronic acid levels in blood before surgery

Quantity of hyaluronic acid in blood before surgery

Time frame: 30 minutes

Hyaluronic acid levels in blood after surgery

Quantity of hyaluronic acid in blood after surgery

Time frame: 30 minutes

Hyaluronic acid levels in urine before surgery

Quantity of hyaluronic acid in urine before surgery

Time frame: 30 minutes

Hyaluronic acid levels in urine after surgery

Quantity of hyaluronic acid in urine before surgery

Time frame: 30 minutes

Sydecan -1 levels in blood before surgery

Quantity of Sydecan -1 in blood before surgery

Time frame: 30 minutes

Sydecan -1 levels in blood after surgery

Quantity of Sydecan -1 in blood after surgery

Time frame: 30 minutes

Sydecan -1 levels in urine before surgery

Quantity of Sydecan -1 in urine before surgery

Time frame: 30 minutes

Sydecan -1 levels in urine after surgery

Quantity of Sydecan -1 in urine after surgery

Time frame: 30 minutes