A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.
Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina. This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.
Change in periostin
Total amount of Periostin (pg/30 sec) in gingival crevicular fluid
Time frame: Baseline, 6th week and 3rd month
Change in periodontal clinical parameter
Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)
Time frame: Baseline, 6th week and 3rd month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.