Currently, limited data is available about patients with HIV in the context of the COVID-19 pandemic. People with HIV who have not achieved viral suppression through antiretroviral treatment may have a compromised immune system that leaves them vulnerable to infections and disease progression. However, little is known about the presentation and clinical outcomes of patients with HIV and SARS-CoV-2. Our aim is to characterize the clinical presentation and disease course of COVID-19 in patients with HIV.
Currently, limited data is available about patients with HIV in the context of the COVID-19 pandemic. People with HIV (PWH)/AIDS, or people with HIV who have not achieved viral suppression through antiretroviral treatment may have at higher risk for SARS-CoV-2 infections and disease progression. At present there is no evidence to suggest that there is an increased risk of infection and increased severity of illness for PWH. We know that during the SARS and MERS outbreaks, there were only few case reports of mild disease among PWH. Current clinical data suggest the main mortality risk factors are linked to older age and other co-morbidities. However, some healthy people have also developed severe disease from the SARS-CoV-2 infection. This is a multi-center prospective observational study. Our aim is to characterize the clinical presentation and clinical course of COVID-19 in patients with HIV. Patients with HIV and confirmed SARS-Cov-2 will be identified during routine clinical care in the inpatient or outpatient setting. Contributors will share de-identified demographic data, health history data, and clinical data pertaining the patient's presentation with COVID-19 and outcomes obtained during routine care for their patients, using the secure online data collection tool REDCap.
Study Type
OBSERVATIONAL
Enrollment
412
No intervention, observational study
University of Missouri-Columbia
Columbia, Missouri, United States
Mortality
COVID-19 related death among patients with HIV and COVID-19
Time frame: 30 days
Frequency of patients requiring hospital admissions
Percentage of patients who required hospitalization
Time frame: 30 days
Frequency of patients requiring ICU admissions
Percentage of patients who required ICU admission
Time frame: 30 days
Frequency of respiratory support use
Percentage of patients who required respiratory support (new oxygen use, non-invasive ventilation,or invasive ventilation)
Time frame: 30 days
Frequency of kidney injury
Percentage of patients who developed acute kidney injury defined as increase in baseline creatinine, or use of renal replacement therapy
Time frame: 30 days
Frequency of liver injury
Percentage of patients who developed liver injury defined as increase in baseline ALT
Time frame: 30 days
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