To evaluate the efficacy and safety of Anluohuaxian in blocking the progression of pulmonary fibrosis and improving lung function in patients with COVID-19.
In clinical institutions that enroll patients with corona virus disease 2019, two arms, multi-center, randomized and controlled methods are adopted. Patients are divided into two groups, Anluohuaxian combined with regular treatment group and regular treatment group. 750 patients are expected to be enrolled and the cases are allocated according to the ratio of 2( Anluohuaxian combined with regular treatment group): 1(regular treatment group).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
750
6g each time, twice a day
The Second People's Hospital of Fuyang
Fuyang, Anhui, China
NOT_YET_RECRUITINGEzhou Central Hospital
Wuhan, Hubei, China
NOT_YET_RECRUITINGHuoshenshan Hospital of Wuhan
Wuhan, Hubei, China
Changes in high-resolution computer tomography of the lung
Changes in ground-glass shadows, interstitial or air nodules found on high-resolution computer tomography
Time frame: 3 months
Change in 6-minute walking distance
Time frame: 3 months
Changes in compound physiological index
Time frame: 3 months
Changes in the scores of the St. George's Hospital Respiratory Questionnaire
St. George's Hospital Respiratory Questionnaire range from 0 to 100. 0 stands for no impact on life and 100 stands for extreme impact on life.
Time frame: 3 months
Changes in modified British Medical Research Council Dyspnea Scale (mMRC) scores
mMRC score range from 0 to 4. 0 stands for wheezing only when exercising hard and 4 stands for severe breathing difficulties.
Time frame: 3 months
Changes in vital capacity of the lung
Adult male vital capacity is about 3,500 ml and female is about 2,500 ml.
Time frame: 3 months
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Jinyintan Hospital of Wuhan
Wuhan, Hubei, China
RECRUITINGTongji Hospital of Huazhong University of Science and Technology
Wuhan, Hubei, China
NOT_YET_RECRUITINGWest Hospital Union Hospital Huazhong University of Science and Technology
Wuhan, Hubei, China
NOT_YET_RECRUITINGWuhan Pulmonary Hospital
Wuhan, Hubei, China
NOT_YET_RECRUITINGZhongnan Hospital of Wuhan University
Wuhan, Hubei, China
NOT_YET_RECRUITINGWenzhou Medical University Affiliated First Hospital
Wenzhou, Zhejiang, China
NOT_YET_RECRUITING