Study on Efficacy of Attenuated Zoster Vaccine, Live

Inclusion Criteria: * 01 Healthy volunteers aged 40 years or older; * 02 Able to understand and give informed consent;. * 03 Able to comply with requirements of all clinical trial protocol for completing the study; * 04 Axillary temperature ≤37.0 at the time of enrollment; Exclusion Criteria: * 05 History of herpes zoster; * 06 History of vaccination against herpes zoster or varicella ; * 07 Allergic sensitivity to any of the components (including neomycin) in the study vaccine and a history of severe allergies to other vaccine; * 08 Premenopausal with positive pregnancy test, pregnant or lactating female, or female planning to become pregnant within 6 months; * 09 Subjects with congenital history of immunity deficiency (e.g., primary immunoglobulin deficiency, isolated IgA deficiency, etc.) or family history; * 10 Receipt of immunoglobulins and/or any blood products within the 5 months preceding of study vaccine or planning to receive these products during the study period; * 11 Immunosuppression resulting from disease,such as immunodeficiency, malignant tumor, HIV infection, organ and bone marrow transplantation, leukemia, lymphoma, Hodgkin's disease caused by low immunity; Receipt of immunosuppressive therapy with corticosteroids (except intermittent topical or inhaled corticosteroids \[\< 800 g/ d Beclomethasone or equivalent\]); Other immunosuppressive/cytotoxic treatments (cancer chemotherapy or organ transplantation); * 12 Subjects with acute infections (such as mumps, etc.), chronic infections in the acute phase (such as active untreated tuberculosis, etc.) or any advanced immune disease; * 13 Use of any investigational or non-registered product (drug, biological product or device) other than the study vaccine within 1 month before study vaccination , or planed use during the study period; * 14 Administration or planned administration of any other immunizations within 1 month before study vaccination or scheduled within the study period after study vaccination. * 15 Any non-local antiviral active treatment within 1 month prior to vaccination, including but not limited to acyclovir, famciclovir, valacyclovir and ganciclovir; * 16 Taking certain pharmaceuticals to be like salicylate kind, including aspirin, and diflunisal, or going to take these medicine during the study period. * 17 history of thrombocytopenia or coagulation disorders that may cause subcutaneous injection contraindications; * 18 significant diseases or significant underlying diseases (such as pulmonary heart disease, pulmonary edema, hypertension that cannot be effectively controlled with drugs \[systolic blood pressure ≥160 mmHg, diastolic blood pressure ≥100 mmHg\] that may interfere with or hinder the completion of the study, serious liver and kidney diseases, diabetes with concurrent symptoms, etc.); * 19 Various infectious, suppurative and allergic skin diseases; * 20 History of psychiatric and neurological disorders (e.g., depression, epilepsy or convulsion); * 21 Any other conditions may compromise the safety or availability of participants in the judgment of the investigator.(e.g., malleable psoriasis, chronic pain syndrome, cognitive impairment, severe hearing loss, and other conditions that may interfere with study evaluation).