Role of suPAR in Periodontitis and CVD

University of Messina326 enrolled

Overview

soluble urokinase-type plasminogen activator receptor (suPAR) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and cardiovascular disease (CVD). The investigators compared the impact of gingival health, periodontitis (CP), CHD or of both diseases (CP+CHD) on saliva and serum suPAR levels.

The aim of this study was to evaluate a possible association between both saliva and serum suPAR levels in patients with CP and with CVD and if the serum suPAR levels are mediated by serum CRP.

Study Type

OBSERVATIONAL

Enrollment

326

Conditions

Metabolic Disturbance Periodontal Diseases

Interventions

Observation of suPAR plasma and salivary levelsOTHER

Evaluation of suPAR plasma level and correlation of plasma suPAR levels with periodontal and cardiovascular disease

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of at least 15 teeth * CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; * Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs * Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: * Intake of contraceptives * Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study * Status of pregnancy or lactation * Previous history of excessive drinking * Allergy to local anaesthetic * Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Locations (1)

University of Messina

Messina, Italy

Outcomes

Primary Outcomes

Clinical attachment level

evaluation of changes in clinical attachment level

Time frame: 1-year

Data from ClinicalTrials.gov

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