A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles

Inclusion Criteria: * Age between 19 to 50, healthy male subjects(at screening) * Body weight between 50.0 kg - 100.0 kg, BMI between 18.0 - 28.0 kg/m2 * Subject who totally understand the progress of this clinical trials, make decision by his free will, and signed a consent form to follow the progress Exclusion Criteria: * Subject who has a past or present history of any diseases following below.(liver, kidney, neurology, immunology, pulmonary, endocrine, hematology, oncology, cardiology, mental disorder) * Subject who had GI tract disease(Crohn's disease, ulcer, acute or chronic pancreatitis) or surgery (appendectomy, hernioplasty are excluded) * Serum AST(SGOT), ALT(SGPT)\>2 times upper limit of normal range MDRD eGFR \<80mL/min/1.73m2 * Subject who had drug (Aspirin, antibiotics) hypersensitivity reaction * Subject who already participated in other trials in 3 months * Subject who had whole blood donation in 2 months, or component blood donation in 1 month or transfusion in 1 month currently