The purpose of this study is to evaluate the efficacy and safety of Basiliximab in combination with pegaspargase in the treatment of relapsed/refractory NK/T-cell lymphoma.
The investigators previously found that CD25 was elevated in patients who were resistant to chemotherapy, and CD25 can mediate resistance, which can be reversed by targeting CD25 therapy. Thus, the purpose of this study is to evaluate the efficacy and safety of Basiliximab in combination with pegaspargase in the treatment of relapsed/refractory NK/T-cell lymphoma.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
20mg d1,8, repeated every 3 weeks
2500IU/㎡, d1,repeated every 3 weeks
complete response rate
evaluated by PET-CT scan or MRI, according to 2014 Lugano criteria for lymphoma
Time frame: up to 15 weeks±1 week from start of treatment
overall response rate
evaluated by PET-CT scan or MRI, according to 2014 Lugano criteria for lymphoma
Time frame: up to 15 weeks±1 week from start of treatment
one year progression free survival rate
Progression free survival was caculated from date of enrollment until the date of first documented progression or date of death from any cause, whichever came first
Time frame: From date of enrollment until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 12 months
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