Impact of Aerobic Training on Sleep Quality and Aerobic Fitness in Male Patients With Pulmonary Artery Hypertension

Cairo University30 enrolled

Overview

This study investigated the effect of 12 weeks of aerobic training on sleep quality and aerobic fitness in patients with Pulmonary arterial hypertension(PAH).

Thirty male PAH patients were included in the study. They were randomized into two equal groups; Training group (A) and Control group(B). Right ventricular systolic pressure (RVSP) measured using Doppler Echocardiography , Pittsburg sleep quality index (PSQI) questionnaire with the wrist worn actigraph used for the assessment of sleep disturbance, and Cardiopulmonary exercise testing (CPET) measurements included maximal heart rate and VO2max .All were measured before and after the study period for both groups.The training was a moderate intensity aerobic training on a bicycle ergometer (corresponding to 60% to 70% of the maximal heart rate they reach during peak oxygen uptake in the initial exercise test) for 30 to 45 min/day, 3 sessions/week for 12 weeks (36 sessions).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Pulmonary Artery Hypertension

Interventions

Moderate intensity aerobic trainingOTHER

The exercise program consisted of 5 minutes warm-up, 15-30 minutes of moderate aerobic exercises and 10 minutes cool-down, respectively. Frequency: 3 sessions/week , and Duration:12 weeks.

Eligibility

Sex: MALEMin age: 45 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were clinically stable and compensated under optimized medical therapy * World health organization (WHO) Classification of functional class II to III PAH * Patients with ejection fraction ≥ 40% * Non-smokers * body mass index ≤ 35 kg/m2 Exclusion Criteria: * Any patient with respiratory failure * unstable angina * renal, hepatic or neuromuscular disorders * history of syncopal attacks * uncontrolled systemic hypertension * peripheral vascular disease * serious cardiac dysrhythmias on resting ECG * evidence of severe COPD at pulmonary function testing, * any known musculoskeletal or neurological conditions that might interfere with the execution or the assessment of the exercise

Locations (1)

Faculty of Physical Therapy

Cairo, Egypt

Outcomes

Primary Outcomes

Pulmonary artery systolic pressure (PASP)

Pulsed Doppler Echocardiogram for assessing PASP as calculated from the gradient across the tricuspid valve using the modified Bernoulli equation.

Time frame: change from baseline at 12 weeks

Subjective self-report questionnaire that assesses sleep quality

The Pittsburgh Sleep Quality Index is a subjective self-report questionnaire that assesses sleep quality over a 1-month time interval in different populations It is 5 points score (0 means normal, 5 means severe sleep disturbance)

Time frame: change from baseline at 12 weeks

Determining sleep patterns

Determining sleep patterns by using actigraph to assess suspected certain sleep disorders,

Time frame: change from baseline at 12 weeks

Measuring aerobic fitness

Level of aerobic fitness assessed by using Cardiopulmonary exercise testing (CPET) through incremental exercise intensity until voluntary exhaustion.

Time frame: change from baseline at 12 weeks

Data from ClinicalTrials.gov

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