The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern. Hospitalized COVID-19-positive patients requiring ICU care is increasing along with the course of epidemic. A large number of these patients developed acute respiratory distress syndrome (ARDS) according to current data. However, the related hemodynamic characteristic has so far been rarely described.
The outbreak of COVID-19 is a worldwide concern. To our knowledge, the details of the hemodynamic characteristics of COVID-19 patients have not yet been well described. Besides, the cardiac injury was reported in about 7-17% of hospitalized patients with COVID-19 in previous Chinese publications and is much more common in patients admitted to ICU and non-survivors. However, no systematic assessment, including echocardiography evaluating the left ventricular function of these patients has been declared. In addition, extravascular lung water (EVLW) and pulmonary capillary permeability are two hall markers in ARDS patient's management, and transpulmonary thermodilution is a validated method to provide these values at the bedside. However, no study has reported the characteristic profile of these variables during ARDS caused by SARS-Cov2. A better knowledge of these characteristics would also be helpful in guiding their management.
Study Type
OBSERVATIONAL
Enrollment
60
Obtained by averaging the results of three thermodilution measurements. Each thermodilution is performed by injecting a bolus (15 mL) of cold saline (less than 10°C)
Daily echocardiography evaluation
Bicetre Hospital
Paris, Val-de-Marne, France
Body temperature
Body temperature(°C)
Time frame: Through study completion, an estimation of 6 months
Blood pressure
Blood pressure in mmHg
Time frame: Through study completion, an estimation of 6 months
Pulse (heart rate)
Pulse (heart rate) in times/minute
Time frame: Through study completion, an estimation of 6 months
Respiratory rate
Respiratory rate in times/minute
Time frame: Through study completion, an estimation of 6 months
Data provided by transpulmonary thermodilution-CI
Cardiac index (L/min/m2)
Time frame: Through study completion, an estimation of 6 months
Data provided by transpulmonary thermodilution-GEDV
Global end-diastolic volume(mL/m2)
Time frame: Through study completion, an estimation of 6 months
Data provided by transpulmonary thermodilution-EVLW
Extravascular lung water (mL/kg)
Time frame: Through study completion, an estimation of 6 months
Data provided by transpulmonary thermodilution-PVPI
Pulmonary vascular permeability index
Time frame: Through study completion, an estimation of 6 months
Incidence of abnormal laboratory test results
Time frame: Through study completion, an estimation of 6 months
Incidence of new-onset or reversible systolic left ventricular dysfunction
Left ventricle ejection fraction, Segmental left ventricle contractility, Speckle tracking data of the left and right ventricles, Dimensions of right and left cavities and Diastolic function of left ventricle
Time frame: Through study completion, an estimation of 6 months
Changes of extravascular lung water measured by transpulmonary thermodilution
The worst extravascular lung water
Time frame: Change from baseline extravascular lung water at 6 months
Changes of pulmonary vascular permeability index measured by transpulmonary thermodilution
The worst pulmonary vascular permeability index
Time frame: Change from baseline extravascular lung water at 6 months
Correlation between the hemodynamic characteristics and 90-day mortality
Time frame: Up to 90th day after inclusion
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