Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19

Inclusion Criteria: * Age at least 18 years * Laboratory confirmed diagnosis of infection with SARS-CoV-2 * Admitted to an acute care facility for the treatment of COVID-19 complications * Severe or life threatening COVID-19, or judged by the treating provider to be at high risk of progression to severe or life-threatening disease * Informed consent provided by the patient or healthcare proxy Severe COVID-19 is defined by one or more of the following: * dyspnea * respiratory frequency ≥ 30/min * blood oxygen saturation ≤ 93% * partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300 * lung infiltrates \> 50% within 24 to 48 hours Life-threatening COVID-19 is defined as one or more of the following: * respiratory failure * septic shock * multiple organ dysfunction or failure Exclusion Criteria: * None